Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis

Lipopeptides are currently re-emerging as an interesting subgroup in the peptide research field, having historical applications as antibacterial and antifungal agents and new potential applications as antiviral, antitumor, immune-modulating and cell-penetrating compounds. However, due to their specific structure, chromatographic analysis often requires special buffer systems or the use of trifl...

متن کامل

Determination of cocaine and metabolites in hair by column-switching LC-MS-MS analysis.

A method for rapid, selective, and robust determination of cocaine (CO) and metabolites in 5-mg hair samples was developed and fully validated using a column-switching liquid chromatography-tandem mass spectrometry system (LC-MS-MS). Hair samples were decontaminated, segmented, incubated overnight in diluted HCl, and centrifuged, and the diluted (1:10 with distilled water) extracts were analyze...

متن کامل

[Simultaneous trichothecenes analysis by LC-MS/MS with a pentafluorophenyl column].

We developed a method for simultaneous analysis of nine trichothecenes (nivalenol, deoxynivalenol, fusarenon-X, neosolaniol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, diacetoxyscirpenol, HT-2 toxin, and T-2 toxin). Trichothecenes in samples were extracted with acetonitrile-water (1 : 1) and purified using a QuEChERS kit and a multi-functional cartridge. Then they were quantified by LC-MS...

متن کامل

LC-MS/MS Validation Analysis of Trastuzumab Using dSIL Approach for Evaluating Pharmacokinetics.

Quantitative targeted proteomics based approaches deploy state-of-the-art Liquid chromatography tandem mass spectrometry LC-MS technologies and are evolving as a complementary technique to standard ligand-binding based assays. Advancements in MS technology, which have augmented the specificity, selectivity and sensitivity limits of detection and freedom from antibody generation, have made it am...

متن کامل

Computational Analysis of LC-MS/MS Data for Metabolite Identification

Metabolomics aims at the detection and quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on highresolution, high-accuracy mass spectrometers enables the simultaneous study of hundreds or even thousands of metabolites in one experiment. Liquid chrom...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Pharmaceutical Analysis

سال: 2014

ISSN: 2095-1779

DOI: 10.1016/j.jpha.2013.09.001